The researchers took samples of fresh brain tissue obtained by biopsy or autopsy from 150 donors. Some of them were healthy people, some suffered from Alzheimer’s disease. The scientists then isolated the microglia and sequenced its DNA. This made it possible to reveal the role of the SPI1 gene.
It is noted that a change in its activity changes the work of other genes, which leads to a rearrangement of the work of microglia.
Previously, SPI1 was known as a proto-oncogene whose mutation can lead to cancer.
Prior to that, on July 19, it was reported that scientists have learned to prevent the onset of Alzheimer’s disease 17 years before a diagnosis can be made.
Doctors at the Center for Protein Diagnostics (ProDi) in Germany have developed a sensor that identifies biomarkers of misshaped proteins in the blood. The accumulation of these proteins in the future creates deposits in the brain that lead to the development of Alzheimer’s disease.
The authors of the study are confident that the method they have discovered, with mass implementation, will prevent the disease.
On July 15, it became known that researchers at the University of Texas have developed a new method of treating Alzheimer’s disease, including blood transfusion.
According to experts, the method of blood transfusion reduces the formation of amyloid plaques in the gray matter of the brain, leading to the development of the disease.